Breast cancer: common medications can stop relapse after surgery

After cancer surgery, especially breast cancer, many patients suffer early tumor recurrence. It is unclear why, but new research suggests that common anti-inflammatory medications, reducing pain can prevent it from occurring.
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The response to an early relapse after breast cancer surgery may be closer than we think.
In many types of cancer, especially in advanced keto the case of breast cancer, surgery is often preferred when it comes to removing primary tumors.

However, the recurrence of cancer after surgery is not uncommon to occur.

Some people who have undergone surgery have a higher risk of early recurrence, although the exact causes of why they are not clear at present.

In a new study published in the journal Science Translational Medicine, the first author Jordan Krall and his colleagues – started at the Whitehead Institute for biomedical research in Cambridge, MA, and other institutions – to reveal some tests and investigate how these can be avoided cases of early relapse.

The researchers explained in their report that “the partial interpretation of these findings was clear: in a third of the patients who were diagnosed with local breast cancer, the cancer cells have already been deployed in distant anatomical sites at the time of initial diagnosis” .

Until surgery, these tumor cells can remain in a state of uncertainty, with their damaging potential blocked by an immune response to the body.

“In a subgroup of patients, however,” say the authors, “a small fraction of these cancer cells spreads the clinically malignant renewal eventually spawn metastases from life-threatening tumors [or secondaries.”

However, the study revealed Krall’s team recently in mice ray of hope in the form of some type of available drug normally used to fight pain and reduce inflammation: nonsteroidal anti-inflammatory drugs (NSAIDs).

Non-steroidal anti-inflammatory drugs appear to reduce the risk of early relapse after surgery in patients who are given during surgery.

“This is the first surgical guide after this type of systemic response,” says Kral. “Surgery is necessary to treat many tumors, especially breast cancer, but there are some side effects of surgery, since there are side effects of any treatment.”
Can cancer surgery lead to metastasis?
So far, it has been difficult for researchers and medical professionals to establish a clear causal relationship between cancer surgery and the activation of these cells. However, current studies have indicated that early relapses tend to peak at 12-18 months postoperatively.

In addition, a review analysis conducted in 2010 analyzed the medical data of 327 women who had undergone a mastectomy and were able to detect it dramatically.

Fewer participants who received NSAIDs for postoperative pain had early transition reversals compared to women who had been prescribed opioids for the same reason.

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